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Results of Treatment

Mild thermotherapy, administered in combination with a primary (radiation, chemo or immune) therapy, continues to show clinical benefits in randomized clinical trials for a number of tumor types with minimal side effects.

The mechanisms of action of thermotherapy consist of a plethora of microscopic and macroscopic enhancements of the primary therapies. Therefore, it’s no surprise that randomised clinical trials are demonstrating better results with the same side-effects.

Rationale Head and Neck hyperthermia

Summary of complete local tumor control reported by randomized or nonrandomized two arm clinical studies for various tumor sites with radiotherapy  (RT) (± chemotherapy) versus radiotherapy (± chemotherapy) and loco-regionalhyperthermia. Datta et al. CTR 2015.

Tumor

RT

RT + HT

Odds ratio

95% CI

p

Head & Neck

CR: 183/364, 50.3%

CR: 266/353, 75.3%

3.71

2.55 – 5.38

<0.001

Breast

CR: 88/181, 48.6%

CR: 122/198, 61.6%

2.10

1.34 – 3.30

=0.001

Cervix

CR: 173/263, 65.7%

CR: 200/251, 79.6%

2.19

1.45 – 3.32

<0.001

Rectum

CR: 16/205, 7.8%

CR: 36/208, 17.3%

2.15

1.10 – 4.20

=0.025

Bladder

CR: 35/86, 40.6%

CR: 69/118, 58.4%

2.40

1.25 – 4.62

=0.009

Esophagus

CR: 24/132, 18.2%

CR: 47/162, 29%

2.64

1.34 – 5.20

=0.005

Superficial

CR: 57/169, 33.7%

CR: 75/175, 42.8%

1.48

0.94 – 2.32

=0.091

Lung

CR: 2/70, 2.8%

CR: 7/59, 11.8%

2.69

0.51 – 14.22

=0.243

CR = Complete Remission. CI = Confidence Interval.

Following radiotherapy for head and neck cancer, patients are at risk for developing a recurrent or second tumor. Often re-irradation is required in these patients, which is hampered in dose by the previous irradiation. In the study shown below, we have used a new hyperthermia applicator in order to increase the effectivity of the radiotherapy. By applying hyperthermia in the future, temperature feedback is warranted to apply heat at the maximum dose without toxicity. This means we are well on our way to balance the clinical outcome with the quality of life.

Visit for more information: Feasibility, SAR Distribution, and Clinical Outcome upon Reirradiation and Deep Hyperthermia Using the Hypercollar3D in Head and Neck Cancer Patients

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